Enzyme Capacity Constraints

An enzyme capacity constraint states that a reaction rate is proportional to the concentration of the catalysing enzyme. The proportionality constant (capacity parameter) can be a constant or a function of model parameters such as the growth rate.

ID Enzyme Reaction Direction Type Formula
R_transport_enzyme_forward_capacity R_transport_enzyme R_transport forward <= {k_transporter_efficiency_foreward: {FunctionID: 'k_transporter_efficiency_foreward'
FunctionType: 'michaelisMenten'
IndependentVariable: 'M_Glucose_e'
FunctionParameters: {Vmax: '1.0'
Km: '1.0'}}}
R_UpperGlycolysis_enzyme_forward_capacity R_UpperGlycolysis_enzyme R_UpperGlycolysis forward <= {k_UpperGlycolysis_efficiency_foreward: {FunctionID: 'k_UpperGlycolysis_efficiency_foreward'
FunctionType: 'constant'
IndependentVariable: 'growth_rate'
FunctionParameters: {C: '1.0'}}}
R_CitratCycle_enzyme_forward_capacity R_CitratCycle_enzyme R_CitratCycle forward <= {k_CitratCycle_efficiency_foreward: {FunctionID: 'k_CitratCycle_efficiency_foreward'
FunctionType: 'constant'
IndependentVariable: 'growth_rate'
FunctionParameters: {C: '0.1'}}}
R_AA_synthesis_enzyme_forward_capacity R_AA_synthesis_enzyme R_AA_synthesis forward <= {k_AA_synthesis_efficiency_foreward: {FunctionID: 'k_AA_synthesis_efficiency_foreward'
FunctionType: 'constant'
IndependentVariable: 'growth_rate'
FunctionParameters: {C: '1.0'}}}
R_fermentation_NAD_regeneration_enzyme_forward_capacity R_fermentation_NAD_regeneration_enzyme R_fermentation_NAD_regeneration forward <= {k_fermentation_NAD_regeneration_efficiency_foreward: {FunctionID: 'k_fermentation_NAD_regeneration_efficiency_foreward'
FunctionType: 'constant'
IndependentVariable: 'growth_rate'
FunctionParameters: {C: '1.0'}}}
R_fermentation_ATP_generation_enzyme_forward_capacity R_fermentation_ATP_generation_enzyme R_fermentation_ATP_generation forward <= {k_fermentation_ATP_generation_efficiency_foreward: {FunctionID: 'k_fermentation_ATP_generation_efficiency_foreward'
FunctionType: 'constant'
IndependentVariable: 'growth_rate'
FunctionParameters: {C: '1.0'}}}
R_respiration_enzyme_forward_capacity R_respiration_enzyme R_respiration forward <= {k_respiration_efficiency_foreward: {FunctionID: 'k_respiration_efficiency_foreward'
FunctionType: 'constant'
IndependentVariable: 'growth_rate'
FunctionParameters: {C: '1.0'}}}
R_transport_enzyme_backward_capacity R_transport_enzyme R_transport backward <= {k_transporter_efficiency_backward: {FunctionID: 'k_transporter_efficiency_backward'
FunctionType: 'michaelisMenten'
IndependentVariable: 'M_Glucose_e'
FunctionParameters: {Vmax: '1.0'
Km: '1.0'}}}
R_UpperGlycolysis_enzyme_backward_capacity R_UpperGlycolysis_enzyme R_UpperGlycolysis backward <= {k_UpperGlycolysis_efficiency_backward: {FunctionID: 'k_UpperGlycolysis_efficiency_backward'
FunctionType: 'constant'
IndependentVariable: 'growth_rate'
FunctionParameters: {C: '1.0'}}}
R_CitratCycle_enzyme_backward_capacity R_CitratCycle_enzyme R_CitratCycle backward <= {k_CitratCycle_efficiency_backward: {FunctionID: 'k_CitratCycle_efficiency_backward'
FunctionType: 'constant'
IndependentVariable: 'growth_rate'
FunctionParameters: {C: '1.0'}}}
R_AA_synthesis_enzyme_backward_capacity R_AA_synthesis_enzyme R_AA_synthesis backward <= {k_AA_synthesis_efficiency_backward: {FunctionID: 'k_AA_synthesis_efficiency_backward'
FunctionType: 'constant'
IndependentVariable: 'growth_rate'
FunctionParameters: {C: '1.0'}}}
R_fermentation_NAD_regeneration_enzyme_backward_capacity R_fermentation_NAD_regeneration_enzyme R_fermentation_NAD_regeneration backward <= {k_fermentation_NAD_regeneration_efficiency_backward: {FunctionID: 'k_fermentation_NAD_regeneration_efficiency_backward'
FunctionType: 'constant'
IndependentVariable: 'growth_rate'
FunctionParameters: {C: '1.0'}}}
R_fermentation_ATP_generation_enzyme_backward_capacity R_fermentation_ATP_generation_enzyme R_fermentation_ATP_generation backward <= {k_fermentation_ATP_generation_efficiency_backward: {FunctionID: 'k_fermentation_ATP_generation_efficiency_backward'
FunctionType: 'constant'
IndependentVariable: 'growth_rate'
FunctionParameters: {C: '1.0'}}}
R_respiration_enzyme_backward_capacity R_respiration_enzyme R_respiration backward <= {k_respiration_efficiency_backward: {FunctionID: 'k_respiration_efficiency_backward'
FunctionType: 'constant'
IndependentVariable: 'growth_rate'
FunctionParameters: {C: '1.0'}}}